BACTERIA and IBD
Intestinal Biotech Development explores the gut flora of animal models in cooperation with the Bacteriology Laboratory of the Lille Pharmacy Faculty.
Inflammatory Bowel Diseases (IBD), including Crohn’s disease and ulcerative colitis, is a group of chronic relapsing inflammatory disorders of the intestinal mucosa. Evidence from human studies and animal models provides compelling support that intestinal microbes play a key role in the disease pathogenesis. It appears that intestinal microbes normally present as commensal microbiota may trigger inflammation and perpetuate disease in genetically susceptible individuals. There may also be a shift in the make-up of the commensal flora to a non-physiologic composition that is more prone to disease (termed dysbiosis).
Evidence supports our conclusion
Evidence supports that genetic susceptibility stems from one or more defects in mucosal immune functions, including microbe recognition, barrier function, intercellular communication, and anti-microbial effector mechanisms.