As more and more sophisticated IBD models become available, we have to exploit the unique potential of each model to ask specific questions. Although no single animal model recapitulates all of the pathogenic and clinical features of human IBD, each animal model contributed to the improved understanding of the mechanisms underlying initiation and perpetuation of chronic intestinal inflammation.

Colitis induced by chemical agents:

-The model of colitis induced by TNBS

-The model of colitis induced by DSS (severe or chronic)

- The model of colitis induced by oxazolone

Genetically modified animal model:

IL10-/- mice, TLR deficient mice

Other models can be used:

The CD45RBHi transfer model

The model of ileitis induced by indomethacine

Which model to choose?

Based on our expertise, we are able to propose the most relevant animal model to evaluate the anti-inflammatory properties of the tested compounds among these different models.

Quantitative and qualitative tools will be used to evaluate the effect of the tested compounds at the clinical macroscopical, histological, mRNA and protein levels (for pro- and anti-inflammatory mediators, therapeutic targets).