Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases.
The peroxisome proliferator-activated receptor gamma (PPAR gamma) and its partner, the retinoid X receptor (RXR), are two nuclear receptors that are expressed mainly in adipose tissue and which have a role in lipid metabolism and insulin sensitization. New sites of PPAR gamma/RXR expression have been described, especially in the intestinal tract, pancreas, and liver.
New functions have been attributed to this heterodimer in regulation of inflammation
Concomitantly, new functions have been attributed to this heterodimer in regulation of inflammation, by its inhibition of nuclear factor (NF)-kappaB and via stress-kinase pathways. These new sites and functions of PPAR gamma/RXR have led to novel ideas about pathophysiology of different inflammatory digestive diseases and to development of innovative treatment strategies with PPAR gamma activators.